Roles of the RON3 C-terminal fragment in erythrocyte invasion and blood-stage parasite proliferation in Plasmodium falciparum.

Ito D*, Kondo Y, Takashima E, Iriko H, Thongkukiatkul A, Torii M, Otsuki H*.

Front Cell Infect Microbiol. 2023 Jun 29;13:1197126.  doi: 10.3389/fcimb.2023.1197126. eCollection 2023.

PMID: 37457963

Phylogenetic Analysis of Spotted Fever Group Rickettsia Gene from Ticks and Human Patients in Tottori Prefecture, Japan.

Otsuki H*, Kondo Y, Tademoto S, Ito D.

Yonago Acta Med. 2023 May 13;66(2):246-256. doi: 10.33160/yam.2023.05.013. eCollection 2023 May.

PMID: 37229380 

Cysteine Residues in Region 6 of the Plasmodium yoelii Erythrocyte-Binding-like Ligand That Are Related to Its Localization and the Course of Infection.

Otsuki H*, Kaneko O, Ito D, Kondo Y, Iriko H, Ishino T, Tachibana M, Tsuboi T, Torii M.

Biomolecules. 2023 Mar 2;13(3):458.  doi: 10.3390/biom13030458.

PMID: 36979393

Extracellular vesicles derived from Spirometra erinaceieuropaei plerocercoids inhibit activation of murine macrophage RAW264.7 cells.

Kondo Y, Ito D, Taniguchi R, Tademoto S, Horie T, Otsuki H*.

Parasitol Int. 2023 Mar 2;95:102742.  doi: 10.1016/j.parint.2023.102742.

PMID: 36870444

Suicide rates during social crises: Changes in the suicide rate in Japan after the Great East Japan earthquake and during the COVID-19 pandemic.

Osaki Y*, Otsuki H, Imamoto A, Kinjo A, Fujii M, Kuwabara Y, Kondo Y, Suyama Y.

J Psychiatr Res. 2021 Aug;140:39-44. doi: 10.1016/j.jpsychires.2021.05.035. Epub 2021 May 26.

PMID: 34090102 

Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation.

Kikuchi T*, Dayi M, Hunt VL, Ishiwata K, Toyoda A, Kounosu A, Sun S, Maeda Y, Kondo Y, de Noya BA, Noya O, Kojima S, Kuramochi T, Maruyama H.

Commun Biol. 2021 May 31;4(1):649. doi: 10.1038/s42003-021-02160-8.

PMID: 34059788

Plasmodium yoelii Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein.

Yuguchi T, Kanoi BN, Nagaoka H, Miura T, Ito D, Takeda H, Tsuboi T, Takashima E*, Otsuki H*

Front Cell Infect Microbiol. 2021 Apr 14;11:656620. doi: 10.3389/fcimb.2021.656620. eCollection 2021.

PMID: 33937099 

Why Are COVID-19 Mortality Rates by Country or Region So Different?: An Ecologic Study of Factors Associated with Mortality from Novel Coronavirus Infections by Country.

Osaki Y*, Otsuki H, Imamoto A, Kinjo A, Fujii M, Kuwabara Y, Kondo Y.

Yonago Acta Med. 2021 Jan 21;64(1):80-91. doi: 10.33160/yam.2021.02.011. eCollection 2021 Feb.

PMID: 33642906

Identification of a Novel RAMA/RON3 Rhoptry Protein Complex in Plasmodium falciparum Merozoites.

Ito D, Chen JH, Takashima E, Hasegawa T, Otsuki H, Takeo S, Thongkukiatkul A, Han ET, Tsuboi T*.

Front Cell Infect Microbiol. 2021 Jan 18;10:605367. doi: 10.3389/fcimb.2020.605367. eCollection 2020.

PMID: 33537242

Live-Cell FRET Reveals that Malaria Nutrient Channel Proteins CLAG3 and RhopH2 Remain Associated throughout Their Tortuous Trafficking.

Ahmad M, Manzella-Lapeira J, Saggu G, Ito D, Brzostowski JA, Desai SA*.

mBio. 2020 Sep 8;11(5):e01354-20. doi: 10.1128/mBio.01354-20.

PMID: 32900800

Characterization of mitochondrial carrier proteins of malaria parasite Plasmodium falciparum based on in vitro translation and reconstitution.

Nozawa A, Ito D, Ibrahim M, Santos HJ, Tsuboi T, Tozawa Y*.

Parasitol Int. 2020 Dec;79:102160. doi: 10.1016/j.parint.2020.102160. Epub 2020 Jun 20.

PMID: 32574727

Alternative Activation of Macrophages in Mice Peritoneal Cavities and Diaphragms by Newborn Larvae of Trichinella spiralis.

Itami N, Kondo Y, Tademoto S, Ito D, Fukumoto S, Otsuki H*.

Yonago Acta Med. 2020 Jan 24;63(1):34-41. doi: 10.33160/yam.2020.02.005. eCollection 2020 Feb.

PMID: 32158331

Molecular cloning and characterization of plerocercoid-immunosuppressive factor from Spirometra erinaceieuropaei.

Kondo Y, Ito D, Tademoto S, Itami N, Nishikata S, Takashima E, Tsuboi T, Fukumoto S, Otsuki H*.

Parasitol Int. 2020 Jun;76:102062. doi: 10.1016/j.parint.2020.102062. Epub 2020 Jan 21.

PMID: 31978597

PfMSA180 is a novel Plasmodium falciparum vaccine antigen that interacts with human erythrocyte integrin associated protein (CD47).

Nagaoka H, Sasaoka C, Yuguchi T, Kanoi BN, Ito D, Morita M, Udomsangpetch R, Sattabongkot J, Ishino T, Tsuboi T, Takashima E*.

Sci Rep. 2019 Apr 11;9(1):5923. doi: 10.1038/s41598-019-42366-9.

PMID: 30976034

Antibodies against a Plasmodium falciparum RON12 inhibit merozoite invasion into erythrocytes.

Ito D, Takashima E*, Yamasaki T, Hatano S, Hasegawa T, Miura K, Morita M, Thongkukiatkul A, Diakite M, Long CA, Sattabongkot J, Udomsangpetch R, Iriko H, Ishino T, Tsuboi T*.

Parasitol Int. 2019 Feb;68(1):87-91. doi: 10.1016/j.parint.2018.10.006.

PMID: 30342119

Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes.

Jenwithisuk R, Kangwanrangsan N, Tachibana M, Thongkukiatkul A, Otsuki H, Sattabongkot J, Tsuboi T, Torii M, Ishino T*.

Malar J. 2018 Dec 13;17(1):466. doi: 10.1186/s12936-018-2617-6.

PMID: 30545367 

Guide RNA selection for CRISPR-Cas9 transfections in Plasmodium falciparum.

Ribeiro JM, Garriga M, Potchen N, Crater AK, Gupta A, Ito D, Desai SA*.

Int J Parasitol. 2018 Sep;48(11):825-832. doi: 10.1016/j.ijpara.2018.03.009. Epub 2018 Jun 15.

PMID: 29906414

Plasmodium falciparum Exported Protein 1 is localized to dense granules in merozoites.

Iriko H*, Ishino T, Otsuki H, Ito D, Tachibana M, Torii M, Tsuboi T.

Parasitol Int. 2018 Jun 8;67(5):637-639. doi: 10.1016/j.parint.2018.06.001. [Epub ahead of print]

PMID: 29886341

The malaria parasite RhopH protein complex interacts with erythrocyte calmyrin identified from a comprehensive erythrocyte protein library.

Miura T, Takeo S, Ntege EH, Otsuki H, Sawasaki T, Ishino T, Takashima E, Tsuboi T*.

Biochem Biophys Res Commun. 2018 Jun 2;500(2):261-267. doi: 10.1016/j.bbrc.2018.04.056. Epub 2018 Apr 13.

PMID: 29653104 

Increased Ca++ uptake by erythrocytes infected with malaria parasites: Evidence for exported proteins and novel inhibitors.

Kushwaha AK, Apolis L, Ito D, Desai SA*.

Cell Microbiol. 2018 May 3:e12853. doi: 10.1111/cmi.12853.

PMID: 29726084

PV1, a novel Plasmodium falciparum merozoite dense granule protein, interacts with exported protein in infected erythrocytes.

Morita M, Nagaoka H, Ntege EH, Kanoi BN, Ito D, Nakata T, Lee JW, Tokunaga K, Iimura T, Torii M, Tsuboi T, Takashima E*.

Sci Rep. 2018 Feb 27;8(1):3696. doi: 10.1038/s41598-018-22026-0.

PMID: 29487358 

Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization.

Tachibana M, Suwanabun N, Kaneko O, Iriko H, Otsuki H, Sattabongkot J, Kaneko A, Herrera S, Torii M*, Tsuboi T*.

Vaccine. 2015 Apr 15;33(16):1901-8. doi: 10.1016/j.vaccine.2015.03.008. Epub 2015 Mar 10.

PMID: 25765968

The rodent malaria lactate dehydrogenase assay provides a high throughput solution for in vivo vaccine studies.

Otsuki H*, Yokouchi Y, Iyoku N, Tachibana M, Tsuboi T, Torii M.

Parasitol Int. 2015 Aug;64(4):60-3. doi: 10.1016/j.parint.2015.02.001. Epub 2015 Feb 19.

PMID: 25701649

Suppression of IP-10/CXCL10 gene expression in LPS- and/or IFN-γ-stimulated macrophages by parasite-secreted products.

Fukumoto S*, Hiroi M, Dirgahayu P, Miura K, Tademoto S, Otsuki H, Ohmori Y.

Cell Immunol. 2012 Mar-Apr;276(1-2):101-9. doi: 10.1016/j.cellimm.2012.04.007. Epub 2012 Apr 30.

PMID: 22608126

Natural infection of Plasmodium falciparum induces inhibitory antibodies against gametocyte development in human hosts.

Tonwong N, Sattabongkot J, Tsuboi T, Iriko H, Takeo S, Sirichaisinthop J, Udomsangpetch R*.

Jpn J Infect Dis. 2012;65(2):152-6.

PMID: 22446123 

Plasmodium vivax gametocyte protein Pvs230 is a transmission-blocking vaccine candidate.

Tachibana M, Sato C, Otsuki H, Sattabongkot J, Kaneko O, Torii M*, Tsuboi T*.

Vaccine. 2012 Feb 27;30(10):1807-12. doi: 10.1016/j.vaccine.2012.01.003. Epub 2012 Jan 11.

PMID: 22245309

Discovery of GAMA, a Plasmodium falciparum merozoite micronemal protein, as a novel blood-stage vaccine candidate antigen.

Arumugam TU, Takeo S, Yamasaki T, Thonkukiatkul A, Miura K, Otsuki H, Zhou H, Long CA, Sattabongkot J, Thompson J, Wilson DW, Beeson JG, Healer J, Crabb BS, Cowman AF, Torii M, Tsuboi T*.

Infect Immun. 2011 Nov;79(11):4523-32. doi: 10.1128/IAI.05412-11. Epub 2011 Sep 6.

PMID: 21896773 

N-terminal prodomain of Pfs230 synthesized using a cell-free system is sufficient to induce complement-dependent malaria transmission-blocking activity.

Tachibana M, Wu Y, Iriko H, Muratova O, MacDonald NJ, Sattabongkot J, Takeo S, Otsuki H, Torii M*, Tsuboi T*.

Clin Vaccine Immunol. 2011 Aug;18(8):1343-50. doi: 10.1128/CVI.05104-11. Epub 2011 Jun 29.

PMID: 21715579

Plasmodial ortholog of Toxoplasma gondii rhoptry neck protein 3 is localized to the rhoptry body.

Ito D, Han ET, Takeo S, Thongkukiatkul A, Otsuki H, Torii M, Tsuboi T*.

Parasitol Int. 2011 Jun;60(2):132-8. doi: 10.1016/j.parint.2011.01.001. Epub 2011 Jan 13.

PMID: 21237287

Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence.

Otsuki H, Kaneko O*, Thongkukiatkul A, Tachibana M, Iriko H, Takeo S, Tsuboi T, Torii M.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7167-72. doi: 10.1073/pnas.0811313106. Epub 2009 Apr 3.

PMID: 19346470

Diplogonoporiasis in Japan: genetic analyses of five clinical isolates.

Arizono N*, Fukumoto S, Tademoto S, Yamada M, Uchikawa R, Tegoshi T, Kuramochi T.

Parasitol Int. 2008 Jun;57(2):212-6.

PMID: 17980651

A glycoprotein from Spirometra erinaceieuropaei plerocercoids suppresses osteoclastogenesis and proinflammatory cytokine gene expression.

Kina Y, Fukumoto S*, Miura K, Tademoto S, Nunomura K, Dirgahayu P, Hirai K.

Int J Parasitol. 2005 Nov;35(13):1399-406. Epub 2005 Jul 18.

PMID: 16051245

Excretory/secretory products from plerocercoids of Spirometra erinaceieuropaei suppress interleukin-1beta gene expression in murine macrophages.

Dirgahayu P, Fukumoto S, Tademoto S, Kina Y, Hirai K*.

Int J Parasitol. 2004 Apr;34(5):577-84.

PMID: 15064122

Excretory/secretory products from plerocercoids of Spirometra erinaceieuropaei suppress the TNF-alpha gene expression by reducing phosphorylation of ERK1/2 and p38 MAPK in macrophages.

Dirgahayu P, Fukumoto S, Miura K, Hirai K*.

Int J Parasitol. 2002 Aug;32(9):1155-62.

PMID: 12117498

Excretory/secretory products from plerocercoids of Spirometra erinaceieuropaei suppress gene expressions and production of tumor necrosis factor-alpha in murine macrophages stimulated with lipopolysaccharide or lipoteichoic acid.

Miura K*, Fukumoto S, Dirgahayu P, Hirai K.

Int J Parasitol. 2001 Jan;31(1):39-47.

PMID: 11165269

Differential expression and regulation of chemokines JE, KC, and IP-10 gene in primary cultured murine hepatocytes.

Wang H, Gao X, Fukumoto S, Tademoto S, Sato K, Hirai K*.

J Cell Physiol. 1999 Nov;181(2):361-70.

PMID: 10497315

Post-isolation inducible nitric oxide synthase gene expression due to collagenase buffer perfusion and characterization of the gene regulation in primary cultured murine hepatocytes.

Wang H, Gao X, Fukumoto S, Tademoto S, Sato K, Hirai K*.

J Biochem. 1998 Nov;124(5):892-9.

PMID: 9792910 

Excretory/secretory products of plerocercoids of Spirometra erinaceieuropaei induce the expression of inducible nitric oxide synthase mRNA in murine hepatocytes.

Wang H, Tanihata T, Fukumoto S, Hirai K*.

Int J Parasitol. 1997 Apr;27(4):367-75.

PMID: 9184928

Comparison of isozyme patterns between Spirometra erinacei and Spirometra mansonoides by isoelectric focusing.

Fukumoto S, Tsuboi T, Hirai K, Phares CK.

J Parasitol. 1992 Aug;78(4):735-8.

PMID: 1386110

The molecular phylogenic tree of the genus Trichinella constructed from isozyme patterns.

Fukumoto S*, Nagai D, Yazaki S, Kamo H, Yamaguchi T.

Parasitol Res. 1988;74(6):574-80.

PMID: 3057491

The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum.

Takashima E*, Otsuki H, Morita M, Ito D, Nagaoka H, Yuguchi T, Hassan I, Tsuboi T*.

Biomolecules. 2024 Jan 12;14(1):100.  doi: 10.3390/biom14010100.

PMID: 38254700