愛媛大学大学院 医学系研究科 博士課程

鳥取大学 医学部 医学科

鳥取大学 医学部 医学科 感染制御学講座 医動物学分野　教授

鳥取大学 医学部 医学科 感染制御学講座 医動物学分野　准教授

南フロリダ大学　研究員

鳥取大学 医学部 医学科 感染制御学講座 医動物学分野　講師

愛媛大学 医学系研究科 寄生病原体学　助教

愛媛大学 医学部 医学科 寄生病原体学　助手

病院 研修医

Roles of the RON3 C-terminal fragment in erythrocyte invasion and blood-stage parasite proliferation in Plasmodium falciparum.

Ito D*, Kondo Y, Takashima E, Iriko H, Thongkukiatkul A, Torii M, Otsuki H*.

Front Cell Infect Microbiol. 2023 Jun 29;13:1197126.  doi: 10.3389/fcimb.2023.1197126. eCollection 2023.

PMID: 37457963

Phylogenetic Analysis of Spotted Fever Group Rickettsia Gene from Ticks and Human Patients in Tottori Prefecture, Japan.

Otsuki H*, Kondo Y, Tademoto S, Ito D.

Yonago Acta Med. 2023 May 13;66(2):246-256. doi: 10.33160/yam.2023.05.013. eCollection 2023 May.

PMID: 37229380

Cysteine Residues in Region 6 of the Plasmodium yoelii Erythrocyte-Binding-like Ligand That Are Related to Its Localization and the Course of Infection.

Otsuki H*, Kaneko O, Ito D, Kondo Y, Iriko H, Ishino T, Tachibana M, Tsuboi T, Torii M.

Biomolecules. 2023 Mar 2;13(3):458.  doi: 10.3390/biom13030458.

PMID: 36979393

Extracellular vesicles derived from Spirometra erinaceieuropaei plerocercoids inhibit activation of murine macrophage RAW264.7 cells.

Kondo Y, Ito D, Taniguchi R, Tademoto S, Horie T, Otsuki H*.

Parasitol Int. 2023 Mar 2;95:102742.  doi: 10.1016/j.parint.2023.102742.

PMID: 36870444

Suicide rates during social crises: Changes in the suicide rate in Japan after the Great East Japan earthquake and during the COVID-19 pandemic.

Osaki Y*, Otsuki H, Imamoto A, Kinjo A, Fujii M, Kuwabara Y, Kondo Y, Suyama Y.

J Psychiatr Res. 2021 Aug;140:39-44. doi: 10.1016/j.jpsychires.2021.05.035. Epub 2021 May 26.

PMID: 34090102 

Plasmodium yoelii Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein.

Yuguchi T, Kanoi BN, Nagaoka H, Miura T, Ito D, Takeda H, Tsuboi T, Takashima E*, Otsuki H*

Front Cell Infect Microbiol. 2021 Apr 14;11:656620. doi: 10.3389/fcimb.2021.656620. eCollection 2021.

PMID: 33937099

Why Are COVID-19 Mortality Rates by Country or Region So Different?: An Ecologic Study of Factors Associated with Mortality from Novel Coronavirus Infections by Country.

Osaki Y, Otsuki H, Imamoto A, Kinjo A, Fujii M, Kuwabara Y, Kondo Y.

Yonago Acta Med. 2021 Jan 21;64(1):80-91. doi: 10.33160/yam.2021.02.011. eCollection 2021 Feb.

PMID: 33642906

Identification of a Novel RAMA/RON3 Rhoptry Protein Complex in Plasmodium falciparum Merozoites.

Ito D, Chen JH, Takashima E, Hasegawa T, Otsuki H, Takeo S, Thongkukiatkul A, Han ET, Tsuboi T.

Front Cell Infect Microbiol. 2021 Jan 18;10:605367. doi: 10.3389/fcimb.2020.605367. eCollection 2020.

PMID: 33537242 

Alternative Activation of Macrophages in Mice Peritoneal Cavities and Diaphragms by Newborn Larvae of Trichinella spiralis.

Itami N, Kondo Y, Tademoto S, Ito D, Fukumoto S, Otsuki H*.

Yonago Acta Med. 2020 Jan 24;63(1):34-41. doi: 10.33160/yam.2020.02.005. eCollection 2020 Feb.

PMID: 32158331 

Molecular cloning and characterization of plerocercoid-immunosuppressive factor from Spirometra erinaceieuropaei.

Kondo Y, Ito D, Tademoto S, Itami N, Nishikata S, Takashima E, Tsuboi T, Fukumoto S, Otsuki H*.

Parasitol Int. 2020 Jun;76:102062. doi: 10.1016/j.parint.2020.102062. Epub 2020 Jan 21.

PMID: 31978597

Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes.

Jenwithisuk R, Kangwanrangsan N, Tachibana M, Thongkukiatkul A, Otsuki H, Sattabongkot J, Tsuboi T, Torii M, Ishino T*.

Malar J. 2018 Dec 13;17(1):466. doi: 10.1186/s12936-018-2617-6.

PMID: 30545367 

Plasmodium falciparum Exported Protein 1 is localized to dense granules in merozoites.

Iriko H*, Ishino T, Otsuki H, Ito D, Tachibana M, Torii M, Tsuboi T.

Parasitol Int. 2018 Oct;67(5):637-639. doi: 10.1016/j.parint.2018.06.001. Epub 2018 Jun 8.

PMID: 29886341

The malaria parasite RhopH protein complex interacts with erythrocyte calmyrin identified from a comprehensive erythrocyte protein library.

Miura T, Takeo S, Ntege EH, Otsuki H, Sawasaki T, Ishino T, Takashima E, Tsuboi T*.

Biochem Biophys Res Commun. 2018 Jun 2;500(2):261-267. doi: 10.1016/j.bbrc.2018.04.056. Epub 2018 Apr 13.

PMID: 29653104

Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization.

Tachibana M, Suwanabun N, Kaneko O, Iriko H, Otsuki H, Sattabongkot J, Kaneko A, Herrera S, Torii M*, Tsuboi T*.

Vaccine. 2015 Apr 15;33(16):1901-8. doi: 10.1016/j.vaccine.2015.03.008. Epub 2015 Mar 10.

PMID: 25765968

The rodent malaria lactate dehydrogenase assay provides a high throughput solution for in vivo vaccine studies.

Otsuki H*, Yokouchi Y, Iyoku N, Tachibana M, Tsuboi T, Torii M.

Parasitol Int. 2015 Aug;64(4):60-3. doi: 10.1016/j.parint.2015.02.001. Epub 2015 Feb 19.

PMID: 25701649

Suppression of IP-10/CXCL10 gene expression in LPS- and/or IFN-γ-stimulated macrophages by parasite-secreted products.

Fukumoto S*, Hiroi M, Dirgahayu P, Miura K, Tademoto S, Otsuki H, Ohmori Y.

Cell Immunol. 2012 Mar-Apr;276(1-2):101-9. doi: 10.1016/j.cellimm.2012.04.007. Epub 2012 Apr 30.

PMID: 22608126

Plasmodium vivax gametocyte protein Pvs230 is a transmission-blocking vaccine candidate.

Tachibana M, Sato C, Otsuki H, Sattabongkot J, Kaneko O, Torii M*, Tsuboi T*.

Vaccine. 2012 Feb 27;30(10):1807-12. doi: 10.1016/j.vaccine.2012.01.003. Epub 2012 Jan 11.

PMID: 22245309

Discovery of GAMA, a Plasmodium falciparum merozoite micronemal protein, as a novel blood-stage vaccine candidate antigen.

Arumugam TU, Takeo S, Yamasaki T, Thonkukiatkul A, Miura K, Otsuki H, Zhou H, Long CA, Sattabongkot J, Thompson J, Wilson DW, Beeson JG, Healer J, Crabb BS, Cowman AF, Torii M, Tsuboi T*.

Infect Immun. 2011 Nov;79(11):4523-32. doi: 10.1128/IAI.05412-11. Epub 2011 Sep 6.

PMID: 21896773

N-terminal prodomain of Pfs230 synthesized using a cell-free system is sufficient to induce complement-dependent malaria transmission-blocking activity.

Tachibana M, Wu Y, Iriko H, Muratova O, MacDonald NJ, Sattabongkot J, Takeo S, Otsuki H, Torii M*, Tsuboi T*.

Clin Vaccine Immunol. 2011 Aug;18(8):1343-50. doi: 10.1128/CVI.05104-11. Epub 2011 Jun 29.

PMID: 21715579

Plasmodial ortholog of Toxoplasma gondii rhoptry neck protein 3 is localized to the rhoptry body.

Ito D, Han ET, Takeo S, Thongkukiatkul A, Otsuki H, Torii M, Tsuboi T*.

Parasitol Int. 2011 Jun;60(2):132-8. doi: 10.1016/j.parint.2011.01.001. Epub 2011 Jan 13.

PMID: 21237287

Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence.

Otsuki H, Kaneko O*, Thongkukiatkul A, Tachibana M, Iriko H, Takeo S, Tsuboi T, Torii M.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7167-72. doi: 10.1073/pnas.0811313106. Epub 2009 Apr 3.

PMID: 19346470

A small-scale systematic analysis of alternative splicing in Plasmodium falciparum.

Iriko H, Jin L, Kaneko O, Takeo S, Han ET, Tachibana M, Otsuki H, Torii M, Tsuboi T*.

Parasitol Int. 2009 Jun;58(2):196-9. doi: 10.1016/j.parint.2009.02.002. Epub 2009 Mar 5.

PMID: 19268714

Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoites.

Cao J, Kaneko O*, Thongkukiatkul A, Tachibana M, Otsuki H, Gao Q, Tsuboi T, Torii M.

Parasitol Int. 2009 Mar;58(1):29-35. doi: 10.1016/j.parint.2008.09.005. Epub 2008 Oct 7.

PMID: 18952195

Disruption of the Plasmodium berghei 2-Cys peroxiredoxin TPx-1 gene hinders the sporozoite development in the vector mosquito.

Yano K, Otsuki H, Arai M, Komaki-Yasuda K, Tsuboi T, Torii M, Kano S, Kawazu S*.

Mol Biochem Parasitol. 2008 Jun;159(2):142-5. doi: 10.1016/j.molbiopara.2008.03.002. Epub 2008 Mar 13.

PMID: 18417228

Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates.

Tsuboi T*, Takeo S, Iriko H, Jin L, Tsuchimochi M, Matsuda S, Han ET, Otsuki H, Kaneko O, Sattabongkot J, Udomsangpetch R, Sawasaki T, Torii M, Endo Y.

Infect Immun. 2008 Apr;76(4):1702-8. doi: 10.1128/IAI.01539-07. Epub 2008 Feb 11.

PMID: 18268027

Diversity and evolution of the rhoph1/clag multigene family of Plasmodium falciparum.

Iriko H, Kaneko O*, Otsuki H, Tsuboi T, Su XZ, Tanabe K, Torii M.

Mol Biochem Parasitol. 2008 Mar;158(1):11-21. Epub 2007 Nov 17.

PMID: 18155305

The Plasmodium vivax homolog of the ookinete adhesive micronemal protein, CTRP.

Kaneko O, Templeton TJ, Iriko H, Tachibana M, Otsuki H, Takeo S, Sattabongkot J, Torii M, Tsuboi T*.

Parasitol Int. 2006 Sep;55(3):227-31. Epub 2006 Jul 5.

PMID: 16822707

Nasal immunization with a malaria transmission-blocking vaccine candidate, Pfs25, induces complete protective immunity in mice against field isolates of Plasmodium falciparum.

Arakawa T, Komesu A, Otsuki H, Sattabongkot J, Udomsangpetch R, Matsumoto Y, Tsuji N, Wu Y, Torii M, Tsuboi T*.

Infect Immun. 2005 Nov;73(11):7375-80.

PMID: 16239536

Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complex.

Kaneko O*, Yim Lim BY, Iriko H, Ling IT, Otsuki H, Grainger M, Tsuboi T, Adams JH, Mattei D, Holder AA, Torii M.

Mol Biochem Parasitol. 2005 Sep;143(1):20-8.

PMID: 15953647

The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum.

Takashima E*, Otsuki H, Morita M, Ito D, Nagaoka H, Yuguchi T, Hassan I, Tsuboi T*.

Biomolecules. 2024 Jan 12;14(1):100.  doi: 10.3390/biom14010100.

PMID: 38254700

The wheat germ cell-free protein synthesis system: a key tool for novel malaria vaccine candidate discovery.

Tsuboi T*, Takeo S, Arumugam TU, Otsuki H, Torii M.

Acta Trop. 2010 Jun;114(3):171-6. doi: 10.1016/j.actatropica.2009.10.024. Epub 2009 Nov 11. Review.

PMID: 19913490

第77回日本寄生虫学会大会 ベストプレゼンテーション賞